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2 edition of Potential cytoprotective role for UDP-glucoronosyltransferases (UGTs) in chemical carcinogenesis: genotoxicity and cytotoxicity of benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts found in the catalog.

Potential cytoprotective role for UDP-glucoronosyltransferases (UGTs) in chemical carcinogenesis: genotoxicity and cytotoxicity of benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts

Diana Stephanie Vienneau

Potential cytoprotective role for UDP-glucoronosyltransferases (UGTs) in chemical carcinogenesis: genotoxicity and cytotoxicity of benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts

by Diana Stephanie Vienneau

  • 333 Want to read
  • 21 Currently reading

Published .
Written in English


The Physical Object
Pagination1 v., 156 leaves
Number of Pages156
ID Numbers
Open LibraryOL21264349M

ABSTRACT A nomenclature system for the UDP glucuronosyltransferase superfamily is proposed, based on divergent evolution of the genes. A total of 26 distinct cDNAs in five mammalian species have be. @article{osti_, title = {DHA down-regulates phenobarbital-induced cytochrome P 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation}, author = {Li, C -C and Lii, C -K and Liu, K -L and Yang, J -J and Chen, H.-W.}, abstractNote = {The constitutive androstane receptor (CAR) plays an important role in regulating the expression of detoxifying enzymes.

Taurine 8 represents the combined efforts of investigators on the roles of the amino acid taurine on human health and disease. The chapters covered in this book are directly derived from presentations of the contributors at the 18th International Taurine Meeting held in Marrakech, Morocco in April extension in daf-2 mutants [24,25,26,27,28,29,30,31]. The potential influence of diverse cytoprotective functions on longevity is underscored by the heat, ROS and toxin resistance of long-lived animals. Consistent with the stress-tolerant phenotypes of long-lived animals, cytoprotective mechanisms are activated in long-lived mutants.

  Nutraceuticals are defined as a food or food ingredients that prevent and treat diseases. They contain dietary supplements like proteins, vitamins and minerals, compound derived from natural sources. They have functions about delaying, preventing and treating chronic inflammatory diseases due to the presence of the phytochemicals. They have anti-inflammatory effects by inhibiting of the. Julia K. Ostermann, Anne Berghöfer, Frank Andersohn, Felix Fischer, Frequency and clinical relevance of potential cytochrome P drug interactions in a psychiatric patient population – an analysis based on German insurance claims data, BMC Health Services Research, /s, .


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Potential cytoprotective role for UDP-glucoronosyltransferases (UGTs) in chemical carcinogenesis: genotoxicity and cytotoxicity of benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts by Diana Stephanie Vienneau Download PDF EPUB FB2

These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections.

(4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID merits further research. Controlled clinical trials are needed. View Full-TextAuthor: Gregorio Martínez-Sánchez, Adriana Schwartz, Vincenzo Di Donna.

These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID merits further research.

Controlled clinical trials are : Gregorio Martínez-Sánchez, Adriana Schwartz, Vincenzo Di Donna. The induction of cytoprotective autophagy requires the accumulation of glucose inside the hypoxic cells.

Glioma cells [] and endothelial cells treated with silibinin, a flavonoid extract, are protected from the glucose-induced damage via activation of autophagy [].The glucose is processed via glycolysis, yielding ATP for ATP-dependent detoxification of the stress stimuli [].Cited by: 2.

Protective Effect of Fenofibrate on Oxidative Stress-Induced Apoptosis in Retinal–Choroidal Vascular Endothelial Cells: Implication for Diabetic Retinopathy Treatment. Title:Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions VOLUME: 13 ISSUE: 5 Author(s):Li Li, Haihong Hu, Siyun Xu, Quan Zhou and Su Zeng Affiliation:Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road, HangzhouCited by:   Author Summary Many mutations that increase animal lifespan also confer stress tolerance, suggesting that cytoprotective mechanisms underpin the regulation of longevity.

It has not been established, however, whether the induction of individual cytoprotective pathways is essential for lifespan extension, or merely correlated. To establish whether the regulatory pathways for the. The UDP-glucuronosyltransferase family. UDP-glucuronosyltransferases (UGTs, EC ) are a multigenic family of enzymes responsible for the glucuronidation reaction, a main process of phase II xenobiotic biotransformation (Mackenzie et al., ).Products of phase I reactions mediated by Pdependent monooxygenases are major substrates of UGTs, although substances which.

Parkinson's disease (PD) is a widespread neurodegenerative disorder characterized by the progressive loss of neurons. The accumulation of aggregated f. In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the formation of water-soluble metabolites originating from normal dietary processes, cellular catabolism, or exposure to drugs and xenobiotics.

This classic detoxification process, which led to the discovery nearly Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.

UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression.

Jim Kaput, PhD, is the founder, President, and Chief Scientific Officer of NutraGenomics, Inc. Raymond L. Rodriguez, PhD, is Professor of Molecular and Cellular Biology and Director of the Centerof Excellence in Nutritional Genomics at the University of California, Davis.

Mast cells (MCs) arise in situ from circulating stem cell factor (SCF)-dependent committed progenitors (PrMCs) and accumulate at sites of allergic mucosal inflammation. We hypothe. Vitamin C is an essential dietary nutrient for the biosynthesis of collagen and a co-factor in the biosynthesis of catecholamines, L-carnitine, cholesterol, amino acids, and some peptide hormones.

Induction of UGT1A1 following activation of the Nrf2-Keap1 signaling pathway by oxidants, such as tert-butylhydroquinone, implicates a potential role for the AREs responding to. When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of ppm.

View full-text Article. Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of lipid hydroperoxides: the products of LOX catalysis. To provide insight on their role, human embryonic kidney cells were transfected to overexpress each of the human isoforms associated with disease, 5-LOX, pLOX, and LOX-1, which.

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease).

Tamoxifen (TAM) is a selective estrogen receptor modulator that is widely used in the prevention and treatment of estrogen receptor-positive (ER +) breast use has significantly contributed to a decline in breast cancer mortality, since breast cancer patients treated with TAM for 5 years exhibit a % reduction in both the rate of disease recurrence after 10 years of patient.

The increase in life expectancy leads to the possibility of development chronic diseases, from special physiological conditions as occurs in the menopause, which is defined as the permanent cessation of ovulation, marked by the end of menstruation.

It has been related to decreased ovarian function that occurs around an age of 45 years. This event involves the reduction in estrogen production. Book; 1. 9. Citations / H-Index Citations. 14 h-index. Therapeutic and Cytoprotective role Funding Agency: DST.

Principal Invistegator Identification and validation of novel notch signaling pathway inhibitors as potential anticancer agents of natural origin Funding Agency: .Cytochromes P (CYPs) are a large group of hemeproteins located on mitochondrial membranes or the endoplasmic reticulum.

They play a crucial role in the metabolism of endogenous and exogenous molecules. The activity of CYP is associated with a number of factors including redox potential, protein conformation, the accessibility of the active site by substrates, and others.Coffee in Health and Disease Prevention presents a comprehensive look at the compounds in coffee, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses.

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